Ineffectiveness of an anticoagulant in South Asians: a genetic mutation in question

2023-08-27 12:03:55

The clopidogrel is commonly used to prevent THE heart attacks and strokes by preventing the coagulation sanguine. Researchers from Queen Mary University of London conducted a study of over 40,000 British South Asians. The results revealed that 57% of these individuals had this specific genetic mutation, making clopidogrel ineffective. Alarming, two-thirds of participants who had been prescribed this drug to prevent heart attacks or strokes had this mutation.

Compared to people of European descent, Britons of Bangladeshi and Pakistani descent have a greater risk of three times more likely to suffer recurrent heart attacks. According to the researchers, this higher prevalence of heart attacks might be attributed to failure of clopidogrel treatment. Dr Emma Magavern, lead author of the study funded by the National Institute for Health and Care Research and Barts Charity, highlighted theimportance of using genetic information to determine the effectiveness of clopidogrel following a heart attack. She warned that the absence of this consideration might disadvantage specific groups. This study also highlights the need to include diverse populations in medical trials for a better understanding of drug risks and effects.

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