2023-08-24 11:00:00
“CPACC”. This is the name of the drug that might allow you not to gain weight and stay healthy without depriving yourself. The latter was developed by researchers at the University of Texas Health Science Center in San Antonio (USA). To develop this treatment, they first examined the impact of magnesium on metabolism, ie the production and consumption of energy in cells. This energy, called “ATP”, fuels the body’s processes.
“Magnesium is the fourth most abundant cation, or positively charged ion, in the body following calcium, potassium, and sodium. It plays many key roles in health, including regulating blood sugar and blood pressure. arterial and bone formation, said the team in a statement.
Weight loss: the drug would reduce the risk of obesity and diabetes
When analyzed, excess magnesium was found to slow energy production in the mitochondria, which are the powerhouses of cells. In a study published in the journal Cell Reports, the authors thus decided to delete MRS2, a gene that promotes the transport of magnesium in the mitochondria. This resulted in a more efficient metabolization of sugar and fats in powerhouses.
Then they developed a drug that accomplishes the same thing. Simply put, it limits the amount of magnesium transferred into power plants. “When we give this drug, for a short time, to mice on a diet high in sugars and fats, they start to lose weight. They all get thin,” explained Madesh Muniswamy, author of the work. Additionally, the rodents’ liver and fat tissue showed no signs of fatty liver disease, a complication linked to obesity and type 2 diabetes.
Adverse effects of dietary stress mitigated by lower mitochondrial magnesium
“The reduction in mitochondrial magnesium attenuated the adverse effects of prolonged dietary stress”, said Manigandan Venkatesan, co-author of the study. “These results are the result of several years of work. A drug capable of reducing the risk of cardiometabolic diseases, such as heart attacks and strokes, and also reducing the incidence of liver cancer, which can occur at cause of fatty liver disease, will have a huge impact. We will continue to develop it.”a conclu Madesh Muniswamy.
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