2023-08-09 19:03:27
Researchers developed an injectable form of DHA, an omega-3 fatty acid that can stop the progression of arterial fatty plaques that can lead to heart attacks and strokes. This form of DHA is more effective than its oral counterpart, which is poorly absorbed by the intestines. Studies in mice have shown the promise of this approach for the treatment of atherosclerosis and cardiovascular disease.
DHA (docosahexaenoic acid) is an omega-3 polyunsaturated fatty acid that has long been known for its anti-inflammatory and antioxidant properties. DHA helps prevent atherosclerosis, or the buildup of fatty plaques on the walls of arteries, which is the main cause of heart disease. Although this acid is found in fatty fish such as salmon, DHA is usually taken as an oral supplement. The problem is that it is poorly absorbed by the intestines in this form, making it difficult for it to affect health.
Researchers at the National University of Singapore have developed an injectable form of DHA that better realizes its therapeutic potential. It has proven effective in the fight once morest atherosclerosis and may become a new treatment for heart disease.
The scientists wrapped DHA in a liposomal form to protect it from degradation and increase its concentration in tissues. Liposomes are tiny man-made spherical sacs that can be made from cholesterol and natural, non-toxic phospholipids and are used to carry drugs or other substances into tissues.
To test the therapeutic efficacy of a new atherosclerosis treatment, the researchers fed mice a high-fat diet for four weeks to build up arterial plaques. They then administered control liposomes or DHA liposomes intravenously for eight weeks while continuing the high-fat diet.
It turned out that when released into the bloodstream, DHA liposomes accumulate in arterial plaques and are taken up by macrophages, a type of white blood cell that reduces plaque. The plaque became more stable, making it less likely to rupture and block an artery, followed by a heart attack or stroke.
The results of the study show that injectable DHA is a promising way to stop the progression of atherosclerosis, the researchers say. Injectable nano-drugs can improve the therapeutic effect of DHA once morest atherosclerosis at a dose of 40,000 to 400,000 times lower than oral DHA. It remains to wait for clinical trials in humans.
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