2023-08-04 14:33:07
August 04, 2023
Among the factors linked to the prevention of Alzheimer’s disease, we find a diet rich in oilseeds, sufficient cognitive stimulation and the maintenance of a good level of social relations. The practice of physical activity and in particular muscle mass would also keep us away from this neurodegenerative disease.
Alzheimer’s disease currently affects 17.5% of people over 75 in France. And if the protection once morest this pathology was, among other things, the density of our muscle fibers? The question arose in the laboratory of the team of Professor Iyas Daghlas, neurologist at the University of California.
What put scientists on this track? They noted that many studies have highlighted the fact that obesity seems to expose people to Alzheimer’s disease. This massive excess weight increases inflammation and insulin resistance. As well as a high level of fats in the tissues degrade beta-amyloid proteins involved in brain health. It also seems that low muscle mass exposes you to this neurodegenerative disease, ” without knowing if this muscle wasting occurs before or following the diagnosis “, describe the scientists.
Impedancemetry tells us everything
To go further in their investigations, the scientists conducted the survey among 21,982 volunteers with Alzheimer’s disease and 41,944 people without Alzheimer’s disease. Thanks to a tool called impedancemetry, an electric current made it possible to assess the amount of muscle and fat mass in the arms and legs of the participants. Results, ” large amounts of muscle mass were associated with a modest but statistically robust reduction in Alzheimer’s risk “, continues Professor Daghlas.
The same test was then carried out at the level of the trunk and the waist. And an assessment of cognitive abilities was also carried out. Conclusion: lean muscle mass was correlated with higher cognitive levels, unlike fat mass which was associated with low scores on this point.
Conclusive results, but we need to do more research before spreading these messages in public health recommendations “says Professor Daghlas. In patients with dementia or very early Alzheimer’s disease, ” we still need to determine precisely following what age and from what degree of impairment changes in muscle mass no longer have any effect on slowing down the disease ».
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Source : BMJ Medicine, June 29, 2023 – Ramaroson H, Helmer C, Barberger-Gateau P, Letenneur L, Dartigues JF. [Prevalence of dementia and Alzheimer’s disease among subjects aged 75 years or over: updated results of the PAQUID cohort]. Rev Neurol (Paris) 2003;159(4):405-11.
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Written by : Laura Bourgault – Edited by: Emmanuel Ducreuzet
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