Study Reveals Influence of Mother’s Dementia History on Offspring’s Risk: Findings Published in Academic Journal

2023-07-11 05:36:00

■ Facilitator: Anchor Kim Yeong-soo, Anchor Um Ji-min
■ Telephone connection: Ki-Woong Kim, Professor, Department of Psychiatry, Seoul National University Bundang Hospital

* The text below may differ from the actual content of the broadcast, so please check the broadcast for more accurate information. quote [YTN 더뉴스] Please specify.

◇Anchor> The results of this study have attracted enough attention to be published in an academic journal. First of all, what are the main contents of this research result?

◆Kim Ki-woong> Living in a community of regarding 17,000 people in 5 European countries and 3 Asia-Pacific countries, including Korea, it investigated the family history of dementia among the elderly, and then investigated the effect on the onset of dementia in those currently suffering from dementia, We analyzed the effect on family history. In the past, there have been studies on the effect of parents’ family history of dementia on their offspring’s risk of developing dementia. In general, there were many results that showed an increased risk of developing dementia, but they were inconsistent.

Because of the difference in the effect of mothers and fathers on family history, we thought that the results might come out this way or that way because past studies did not distinguish these things and grouped them together. We divided the family history of dementia and analyzed the effect on the risk of dementia in offspring. Then, the mother’s history of dementia increased the risk of dementia in the offspring by regarding 50%, 1.5 times, and Alzheimer’s disease increased by 1.8 times. On the other hand, the father’s family history increased somewhat, but it did not reach a statistically significant level. In addition, in the case of offspring, it was analyzed that males were relatively more affected by the mother’s dementia family history than females.

◇Anchor> The part to pay attention to in this study is the influence of the mother, and it was found that the risk increased by 51% if the mother had a history of dementia. How can we read this?

◆Kim Ki-woong> Dementia is a complex disease in which a variety of genetic and environmental factors work together to determine whether or not to develop it. However, among the genetic factors that affect the onset of dementia, there are genes that can only be inherited from the mother. For example, genes on the sex chromosome, the X chromosome, and genes in the mitochondria are mostly inherited only from the mother. So, since only women have genes that can transmit the risk, it is assumed that the mother’s family history is relatively more influential than the father’s.

◇Anchor> We prepared a graphic, but I would like you to look at the graphic and explain it. Didn’t you say that if the mother has a history of dementia, the risk is 100% for the son and 68% for the daughter? What does this mean?

◆Kim Ki-woong> That doesn’t mean 100% risk or 68% risk. In the case of men and sons, the relative risk is 100% increased compared to those whose mothers do not have dementia, which means that the risk is doubled. In the case of women, the risk of developing dementia increases by regarding 1.7 times compared to those whose mothers do not have dementia. So it doesn’t mean that all sons will have 100% dementia.

◇Anchor> As you can see now, you are influenced more by your mother than by your father. How do you see this mechanism?

◆Kim Ki-woong> As I mentioned before, the mother’s influence is a little bigger because there are mitochondrial genes or genes on sex chromosomes that only mothers can pass on. In addition, among various complex genetic phenomena, this phenomenon called inpainting is also transmitted from women and mothers, so it is estimated that such things cause this reflection.

Excerpt from conversation: Kim Seo-young, editor of Digital News Team

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