2023-07-10 02:35:18
On 10 July 2023, Medical Genome Center Faculty of Medicine Ramathibodi Hospital In a post on the Center for Medical Genomics Facebook page, it states that…
Recent research suggests that the types and numbers of gut microbiota in people pre-Alzheimer’s dementia differ from those of healthy people.
The Medical Genome Center, Ramathibodi Hospital used specific probes to track the types and amounts of key microbial populations in the gut of a Thai population of 48 strains to detect imbalances. Between ‘good’ and ‘bad’ microorganisms in the gut (Dysbiosis) affecting the health of the individual.
Update 10/7/2023 time 8:00
A research team from the Washington University School of Medicine in the United States Found that the gut microbes of people who detected dementia from brain scans both “asymptomatic group” and The “Alzheimer’s group” had a different type and number of microbes than the healthy group. by publishing research results on the topic Gut microbiome composition may be an indicator of preclinical Alzheimer’s disease in Science Translational Medicine.
The study showed that among people who first detected dementia on PET and MRI scans, they did not have clinical signs of dementia in memory, attention, and functioning. Recognize, language and troubleshooting appear. They found that these groups had significantly different gut bacteria compared to healthy people.
The findings, published in Science Translational Medicine on June 14, 2023, point to light at the end of the tunnel in new diagnoses or treatments. Aimed at gut microbiota for Alzheimer’s disease
The researchers propose that it may be possible to identify individuals at high risk of developing dementia by analyzing their gut microbiome communities. Treatments that target the microbiome can also be selected. or using certain drugs to prevent, delay or treat Alzheimer’s disease. before the severe symptoms are irreparable
However, it is not clear at this time. “Pathological changes in the brain resulting in changes in the gut microbiome” or “gut microbiome resulting in pathological changes in the brain causing Alzheimer’s disease”
Incidentally, if the first is a pathological change in the brain. This results in changes in the gut microbiome. We may be able to use the type and amount of gut microbiome as an indicator of pre-symptomatic Alzheimer’s. and treated with medicine from the beginning
But if the intestinal microbiome results in pathological changes in the brain? The prevention of Alzheimer’s disease can be improved by altering the type and number of intestinal microbiome, for example by taking specific prebiotics and probiotics.
Prebiotics are indigestible fibers that serve as food for the beneficial bacteria in the gut. Prebiotics promote the growth of good bacteria, which can improve digestion and overall gut health. Prebiotics are found in some foods and can be taken in supplements.
Probiotics are beneficial microorganisms for the body if consumed in sufficient quantities. This will help promote digestive health and balance the intestinal microflora. Probiotics can improve digestion. absorption of nutrients and overall gut health Probiotics are available in foods and supplements. and common species include Lactobacillus and Bifidobacterium.
It was previously known that the gut microbiome of Alzheimer’s patients is both different in type and quantity than that of healthy subjects. But no research has explored the type and quantity of microbiome in “Before Alzheimer’s”
during the early stages of Alzheimer’s which may last two decades or more There is an accumulation of amyloid proteins. Beta and tau proteins in the brain, but no signs of neurodegeneration or cognitive decline.
Researchers assessed 164 healthy volunteer participants; About one-third (49) had early, asymptomatic dementia. They found that there was a significant difference in gut bacteria between healthy people and people with preclinical (preclinical) Alzheimer’s disease. These differences were associated with levels of amyloid and tau proteins, but were not associated with neurodegeneration.
These findings point to the potential of the gut microbiome as a potential early screening tool for Alzheimer’s disease. Using stool samples that are easy to collect without having to draw blood.
The research team plans to follow up for another five years to determine whether differences in the intestinal microbiome cause Alzheimer’s disease or result from early Alzheimer’s disease resulting in the microbiome. The gut biome changes. If the link is found and is a significant cause of disease Future treatments may focus on promoting “good” bacteria or eliminating “bad” bacteria in the gut.
Microbiome refers to all microorganisms. This includes bacteria, viruses, fungi and protozoa that live inside the human body. Most of these microorganisms live in the intestines. It is important for maintaining homeostasis and overall health. The microbiome can affect your body and health in the following ways:
1. Digestion: The intestinal microbiome helps break down complex dietary compounds that human cells cannot digest, such as certain fibers. They can break down these substances into short-chain fatty acids such as butyrate, propionate and acetate, which can provide energy to our cells.
2. Immune modulation: The microbiome plays an important role in building and regulating the immune system. in developing a healthy immune response It helps your body distinguish between harmless and potentially dangerous intruders.
3. Mental Health: New research suggests the microbiome may affect mental health. Some studies have found an association between gut microbiota changes and mental health conditions such as anxiety, depression, and neurodevelopmental disorders. including autism and may include Alzheimer’s symptoms
4. Weight control: Gut microbiome composition is linked to body weight. Some bacteria are more common in obese people than in non-obese people. Some studies suggest these bacteria may affect weight by affecting the way we metabolize food and absorb nutrients.
5. Metabolic Health: The gut microbiome has been implicated in many metabolic diseases. including type 2 diabetes and fatty liver disease Changes in the gut microbiome may affect the body’s metabolism and insulin sensitivity.
6. Heart Health: The gut microbiome can affect heart health by affecting factors such as inflammation and cholesterol levels. Certain gut bacteria can produce substances that affect heart health, such as TMAO (trimethylamine N-oxide), which has been linked to atherosclerosis.
7. Skin Health: Recent research suggests that the skin microbiome plays a key role in conditions such as acne, psoriasis and psoriasis. and eczema
The Genome Center selected 48 bacterial strains with “Luminex” technology to measure the imbalance of the intestinal microbial community that affects health (Dysbiosis) that can cause a variety of illnesses. Using 100 tiny beads that can emit up to 100 different shades of light, the beads are attached with special molecules that can specifically bind to the genomes of each microbial species in the sample. The fluorescence is then measured with a machine called a flow cytometer that can read up to 100 shades of fluorescent beads, and the results from the shade analysis will tell us which microorganisms are there. How much is in the sample for accurate examination? inaccurate Because the examination results must be compared with the previous examination periodically (monitoring), while if using advanced genetic decoding technology or next generation sequencing / NGS will have a higher discrepancy Multicenter quality assessment of 16S ribosomal DNA-sequencing for microbiome analyses reveals high inter-center variability.
Therefore, the Luminex microbial assay has the “CE-IVD” or “Conformité Européenne – In Vitro Diagnostic Devices” certificate for use in normal human samples or from patients in European hospitals for the detection of “Dysbiosis”.
Dysbiosis refers to the natural imbalance of microbial communities living in a particular environment. It is most commonly used in reference to the gut microbiota.
The gut microbiome is comprised of trillions of microorganisms. This includes bacteria, viruses, fungi and other single-celled organisms. Lives in the gastrointestinal tract and plays an important role in digestion. functioning of the immune system and overall health
Dysbiosis can be caused by factors such as poor diet, stress, lack of exercise. use of antibiotics and other environmental influences
This imbalance can lead to a decrease in beneficial microbes and an increase in potentially harmful microbes. which may lead to various health problems Some of these health problems include inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), obesity, metabolic syndrome. and even mental health disorders such as anxiety and depression, including “Alzheimer’s”
Restoring a balanced intestinal microflora is essential for maintaining overall health. This can be done through lifestyle changes. (Behavior modification) which includes healthy foods rich in fiber. regular exercise stress management and proper use of antibiotics. In some cases, probiotics and prebiotics may be helpful in promoting a healthy intestinal microbial balance.
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