2023-07-06 08:12:46
Some physical activity is required.
Brazilian scientists from the University of Sao Paulo have named a way to prevent Alzheimer’s disease or delay the onset of symptoms through strength training. The results of the study are published in the journal Frontiers in Neuroscience.
In the experiment, the authors examined genetically modified mice with a mutation that accumulated beta-amyloid plaques associated with Alzheimer’s disease in their brains. The test subjects were specially trained to climb a ladder 110 centimeters high with an inclination of 80 degrees and a distance between the rungs of two centimeters.
Attached to their tails were weights corresponding to 75, 90, and 100 percent of their body weight. The test simulated certain types of strength training for people in fitness centers.
The goal of the specialists was to monitor the neuroprotective processes of animals.
After four weeks of exercise, blood samples were taken from the subjects to measure plasma levels of corticosterone, a hormone that corresponds to cortisol in humans. An increase in the level of this hormone occurs in response to stress, and it also increases the risk of developing Alzheimer’s disease.
The researchers found that corticosterone levels were normal (identical to animals with no signs of dementia) in mice that exercised. Subsequent analysis of their brain tissue showed a decrease in the formation of beta-amyloid plaques.
The findings of the work confirm that physical activity can reverse the neuropathological changes that cause the clinical symptoms of Alzheimer’s disease.
Modern medicine does not stand still and is constantly evolving. Read in the gallery regarding the main medical discoveries of the XXI century:
Two of the three types of polio have been eradicated; the last one is coming. Following the type 2 poliovirus, officially declared eradicated in 2015, type 3 virus ceased to exist on October 24, 2019. The last case of infection was recorded in 2012 in Nigeria. All of this has been made possible by the widespread use of vaccines since the 1950s.
Source: Andrew Wyeth. World of Christina. 1948/wikimedia.org/CC0
Artificial intelligence has learned to predict the structure of proteins. The ability to predict, simply from the sequence of amino acids, what the three-dimensional structure of any protein, of which there are hundreds of thousands in the human body, will not only revolutionize biology, it opens up new possibilities for drug development and the treatment of many diseases.
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Malaria will be defeated. Malaria might be completely eradicated by 2050, according to The Lancet. As one of the decisive measures, it is proposed to change the DNA of mosquitoes, which will lead to their infertility or make them resistant to malarial plasmodia.
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CRISPR/Cas9 is a genome editing technology that allows it to be adapted for treatment. Theoretically, it will make it possible to better study the course of various complex diseases and “reprogram” the diseased organism for recovery.
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Creation of antibodies for viral diseases. Laboratory-created monoclonal antibodies have already revolutionized the treatment of autoimmune diseases and certain types of cancer, but so far their use for treating infections has been limited.
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HIV and AIDS are on the decline. The effectiveness of modern ARV therapy has already been proven, and in recent years several patients from different countries have been completely freed from the diagnosis.
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First coronavirus vaccines in record time. The way humanity reacted to the coronavirus pandemic, of course, cannot be called a standard – but thanks to the active work of the scientific community, it was possible to create effective vaccines very quickly.
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Cancer has been identified through a blood test. In 2020, trials of a universal blood test started in the UK, which allows to detect up to 50 types of cancer at an early stage. The study will be completed in 2023, and if it shows its effectiveness, then by the middle of the decade, blood tests for cancer will become massive.
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Hepatitis C has become completely curable. Literally over the past few years, the effectiveness of drugs from the “gentle killer” has approached 100%. Such progress came with the introduction of interferon-free treatment regimens.
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Alzheimer’s disease will learn to predict. Alzheimer’s blood test is another small medical revolution of 2020. Scientists have learned to identify the relevant biomarkers in blood plasma regarding four years before the onset of the first symptoms of the disease, which means that such a blood test can be included in annual medical examination programs and recommendations for patients.
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