2023-07-06 10:06:00
Institute of Ethnic Medicine Academic Conference on “Research and Development of Thai Herbs to advance to the international level”, having been honored by Assoc. Prof. Dr. Surapoj Wongyai United Nations herbal expert And the research team has presented the important research results of the “Kera” herbal formula, which the results of the herbal formula of Kera were tested in the biochemical laboratory. Kasetsart University (MG) has studied the pharmacological effects of Khera in many aspects. The activity was found to inhibit a wide range of viruses, the effect of the virus entering the cells. anti-inflammatory effect anti-cancer effect The effect causes cancer cells to die.
Assoc.Prof.Dr.Kiatthawee Chuwongkamon Department of Biochemistry Kasetsart University Revealed in the field of virus suppression. It was found to be effective in inhibiting the SARS-CoV-2 virus by inhibiting the main protease with a higher efficiency.Andrographis paniculataUp to 600 times, 500 times higher than Ritronavir.
as well as inhibiting the mechanism of replication of the RdRp coronavirus more effectively than the drug Favipiravir
In addition, it was found to prevent the corona virus from entering the cells. It was found that Khera can help prevent infection by preventing virus from entering cells. at a concentration of 0.5 mg./ml., it can prevent up to 90% of the virus from entering the cells, which has the potential to be studied further.
It was also found effective in inhibiting influenza A virus, dengue virus, AIDS virus, HIV virus, herpes virus, which is an important cause of cervical cancer. These include viruses that infect animals, FIP in cats and FIV, the immunodeficiency virus in cats similar to AIDS in humans.
It has also been found to have anti-inflammatory effects. The mechanism of inhibition of pro-inflammatory cytokines, IL-1b, IL-6 and TNF-alpha, has been shown to induce pneumonia in patients with coronavirus known as cytokines. Kine, as well as having an effect on inflammation in the body of patients with many diseases such as SLE, rheumatoid, while at the same time, it has been found to reduce blood pressure. by inhibiting the enzyme ACE
The research also found that Khera has anti-cancer effect By inhibiting the EGFR protein involved in promoting the growth and proliferation of many cancer cells such as urinary tract cancer, lung cancer, colon cancer. and breast cancer It was found that the drug Khura at a concentration of 100 micrograms per milliliter EGFR inhibition was comparable to erlotinib, a targeted anticancer drug. 1 mcg/mL and found the activity to stimulate P53 protein or tumor protein 53, which is a transcription factor that controls cell cycle. It also has a role to inhibit tumor caspase, making p53 important in cancer suppression of multicellular organisms.
In addition, apoptosis in cancer cells was demonstrated by the activation of a molecular switch called -8 and caspase-9, which are molecular switches for apoptosis. The concentration that can kill half of HCT116 colon cancer cells is 73 µg/ml. This is a concentration value that is considered effective and interesting for further research and development as a herbal formula for cancer.
while Prof. Dr. Suriyan Sukti, Walailak University(Mass.) et al. disclosed the results of research on the safety of taking Kera capsules in volunteers. safe By comparing blood test results, liver function, kidney function, red blood cell count, white blood cell count, CRP (C-reactive protein) and erythrocyte sedimentation count.
side Dr. Payong Thepaksorn et al. revealed the results of a comparative study of drug exposure for infected peopleCOVID-19 with Khera herbs compare with Andrographis paniculata and getting vaccinated The sample of 2,157 people was divided into 3 groups: it was found that the infected group who took andrographis paniculata And get vaccinated have a higher infection rate than those who eat Kerra. Statistically significant (p<0.01)
side Dr. Rangsun Budcha Director of Democrat Hospital and team Revealing a sample of 230 people infected with COVID-19 who come to treat, divided into 2 groups, taking Kerra. and taking molnupiravir It was found that both groups got better. Khera herbs There is no difference in treatment efficacy.
stress Dr. Suwannee Soisong and others Study in a sample group who are infected with the disease. COVID-19 Delta strain by conducting a retrospective study From a group of 2,510 people infected with COVID-19 in Pathum Thani province who received Khera herbs. After receiving Kera herbs, symptoms were found within 7 days, accounting for 67%.
by during the treatment No increase in progression was found. No breathing apparatus was used. no significant side effects No referrals and no patients died from COVID-19 After taking the Khera formula herbal medicine
Tested on Delta strain COVID
For comparative information on the cost and effectiveness of the use of Khera and Favipiravir. in treating patients infected with COVID-19 by Dr. Pusadee Sathong and others fromKing Mongkut’s College of Nursing, Phetchaburi Revealed that the sample was a patient infected with the Delta strain of COVID-19. 4,399 people who received treatment in the Prachathipat Hospital network, Pathum Thani Province and Pathum Thani Provincial Administrative Organization (Pathum Thani Provincial Administrative Organization) used Favipiravir, 2,838 people used the herbal formulation of Kera, 2,510 people.
It was found that 2,799 people who received favipiravir were admitted to field hospitals under the supervision of Democrat Hospital and Democrat Hospital, 77 people were exhausted and needed oxygen.
While those who use Kera herbs receive medicine and stay at home. No more serious referrals were found. when considering the cost of treatment It was found that the patients receiving the drug used Favipiravir. with an average cost of 19,784.14 baht per person, while the Khera herbs cost an average of 750 baht per person.
Dr. Pat book President of the Institute of Ethnic Medicine Revealed that at present, KERA products have been registered with the Food and Drug Administration. Registration number G 40/57 is a fever pill, but with many properties than just a fever pill. which has been confirmed by a medical professional and research results that have been announced at this academic conference Thai herbs, Khera formula is suitable for the situation of Thailand to develop as one of the SolfPower to generate income and reputation for Thailand
All research results will be presented to the Food and Drug Administration (FDA) for registration as a herbal product development. effective in treating COVID-19 This will promote the widespread use of herbs within the country. and exported to the international level
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