2023-07-04 03:02:01
Longevity protein ‘Klotho’… Shows potential as a treatment for restoring brain function in the elderly
↑ Rhesus monkey/Photo = AP Yonhap News
A research team led by Professor Dena Duvall at the University of California, San Francisco (UCSF) published today (4th) in the scientific journal Nature Aging to find out if Klotho, which has recently been shown to improve cognitive function in mice, also affects cognitive function in non-human primates. Bo said that this fact was confirmed in an experiment, and that this shows the potential of Klotho as a treatment for brain function recovery in the elderly.
Cognitive function is a key brain function that is attenuated by aging and age-related diseases such as Alzheimer’s disease.
As the global population ages, cognitive decline has become a challenge for the biomedical community to develop effective pharmacological intervention methods.
Klotho is a transmembrane protein that is one of the longevity proteins known to be involved in insulin sensitivity control and aging.
It has been shown to prolong the lifespan of mice, and in recent experiments with mice, it has been found to increase the function and cognitive abilities of synapses, where nerve cells are connected.
In this study, the research team administered a low-dose Klotho (10 μg per 1 kg of body weight) to 18 rhesus macaques with an average age of 22 years to see if Klotho is also effective in improving cognitive abilities in non-human primates. After administration, tests were performed to evaluate working memory and spatial memory.
As a result, old monkeys who received a single dose of low-dose Klotho significantly improved both working memory and spatial memory, and the improvement in memory lasted for at least two weeks.
However, when the dose of Klotho was increased to 20 μg and 30 μg/kg of body weight, it was found that there was no improvement in cognitive function.
Interestingly, unlike monkeys, the research team showed that cognitive abilities improved as the dose of Klotho was increased in mice experiments.
You pointed out that this might be due to increased complexity.
Professor Duvall said the results of this experiment show that the beneficial effects of Klotho on cognitive function can be applied to non-human primates as well. said.
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