2023-06-26 03:00:00
A research team in Korea has identified that enzymes produced by intestinal microbes maintain the homeostasis of human immunity.
The research team led by Dr. Kim Myung-hee of the Microbiome Convergence Research Center at the Korea Research Institute of Bioscience and Biotechnology announced that the contents were published in the online edition of the international journal ‘Cell Host & Microbe (IF 31.316)’ on the 2nd.
Akkermansia muciniphila, an intestinal microorganism, secretes ‘AmTARS (Akkermansia muciniphila threonyl-tRNA synthetase)’, a protein synthesizing enzyme with anti-inflammatory immune regulation function. It was analyzed that it restores homeostasis by increasing the expression level of ‘anti-inflammatory cytokine’, a factor.
AmTARS, a protein synthesizing enzyme, has also been confirmed to have a function to alleviate diseases by restoring damaged colon tissue.
Accordingly, the research team explained that the ‘AmTARS’ enzyme might be used in the future to develop treatments for inflammatory intractable immune diseases such as inflammatory bowel disease.
Dr. Kim Myung-hee, who conducted the research, said, “The results of this analysis are an example that clearly shows how the human body and the microorganisms (microbiome) living in the human body live in a mutually dependent relationship.”
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