2023-05-24 18:00:00
Banned in the food sector, the additive E171 remains present in toothpastes. Its toxicity is already known, but new research shows that its toxic nanoparticles pass directly into the mucous membranes of the mouth and damage them.
Even if the additive E171 has been banned in food in Europe since 2022, it can be found in toothpaste and pharmaceutical products. New French research reveals that the titanium dioxide nanoparticles, TiO2, it contains pass through the mucous membranes of the mouth pour reach the blood.
Published on May 17 in the journal Nanotoxicologythe research was carried out by scientists from INRAE, in collaboration with the National Metrology and Testing Laboratory of Paris (LNE), indicates a statement.
#RP_INRAE???? Titanium dioxide would also pass through the mucous membranes of the mouth:
???? An additive that can be used in food, cosmetics and pharmaceuticals
????Results to be taken into account in the risk assessment????Read the new study: https://t.co/uNDBZlMyGG pic.twitter.com/Pps7MtCEGC
— INRAE (@INRAE_France) May 17, 2023
Previous animal work has shown that titanium dioxide nanoparticles may be responsible for the development of precancerous cells in the colon, in addition to other effects. Very small, they are ingested into the body, pass into the blood and end up accumulated in liver and spleen. In pregnant women, they can lodge in the placenta and contaminate the fetusrecalls the document.
Absorbed even before the intestine
For the new study, the authors first studied pig mouths and then cultured human mouth cells. The results confirm that these toxic particles are rapidly absorbed by the oral mucosa, well before being absorbed by the intestine. “Once past, these damage DNA cells by subjecting them to oxidative stress, affecting the survival of growing cells, an effect likely to affect the renewal of the oral epithelium”the mucous membrane that lines the inner lining of the lips and the oral cavity, according to the release.
Scientists suggest taking into account direct exposure of the oral cavity to the additive E171 when evaluating risks in humansespecially concerning the use of toothpaste.
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