2023-05-19 07:29:30
Drug-resistant superbugs that cause serious infections pose a public health threat. An antibiotic identified regarding 80 years ago, then forgotten, has just been reanalyzed by scientists.
You may also be interested
[EN VIDÉO] Antibiotic resistance of bacteria, a growing threat Antibiotics have the property of killing or limiting the spread of bacteria. Gold,…
An antibiotic first identified in 1942 might resurface to counter antibiotic-resistant bacteria. According to a new study published in PLOS Biologythe old antibiotic (called nourseothricin) would offer a new way to fight hard-to-treat and potentially deadly infections.
The antibiotic under consideration is a natural product produced by a fungus and which contains two forms of the streptothricin molecule: F and D. According to the authors, it is the first antibiotic discovered with potent activity once morest Gram bacteria. negative, which remain particularly difficult to kill. But the product was abandoned by scientists because it was deemed too toxic for kidney health.
Identification of a less toxic form
Today, researchers have re-examined the molecule thanks to advances in scientific techniques. They found that the F form was far less toxic to the kidneys than the D, while still being very effective at killing drug-resistant Gram-negative bacteria. ” We have found that not only is its activity potent, but it is also highly active once morest the most robust contemporary multidrug-resistant pathogens and acts through a unique mechanism of protein synthesis inhibition said Dr. Kirby in a press release.
Although the antibiotic’s mechanism of action is not yet entirely clear, researchers have already begun to study how to improve natural streptothricins so that they are even more effective once morest superbugs.
1684532492
#antibiotic #forgotten #scientists #prove #effective #superbugs
