“Reviving an 80-Year-Old Antibiotic to Fight Against Multidrug-Resistant Bacteria: A Breakthrough in the Battle Against Antibiotic Resistance”

2023-05-16 18:00:00

Nourseothricin, an antibiotic identified around 80 years ago but left aside since then, might prove effective once morest bacteria responsible for particularly serious infections and whose antibiotic resistance constitutes a strong threat to global health.

Antibiotic resistance is a major public health challenge. Fighting once morest multidrug-resistant bacterial infections requires developing new methods of care, implementing new treatments and rethinking the way we consume antibiotics. In a study published in the journal PLOS Biologyresearchers at Boston University (United States) are bringing an 80-year-old antibiotic that has never been on the market up to date: it might prove to be particularly effective once morest bacterial infections that are difficult to treat and can have serious health consequences.

Antibiotic resistance, a major health problem

Antibiotic resistance is said to have directly caused almost 1.3 million deaths worldwide in 2019according to a study published in 2022 in The Lancet. The generalized and consequent use of antibiotics means that certain bacteria have developed defense mechanisms once morest these treatments, thus limiting their effectiveness or rendering them totally ineffective. However, it is difficult today to do without these drugs which are an integral part of our medical system: “During an operation, we use antibiotics to prevent and treat infections. Many of the treatments for cancer or autoimmune diseases place patients in a state of profound immunosuppression where they are at high risk of infection. Without active antibiotics, these treatments would not be possible and a number of patients would die from infections.” illustrates James Kirby, researcher at Harvard Medical School (Boston, USA) and co-author of the study. And antibiotic resistance spares no one, since humans, animals and the environment are concerned. Treatment with antibiotics is nevertheless one of the foundations of our modern medicine, since the discovery of penicillin in 1928 by Alexander Fleming and his first u[…]

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