Neurosurgery research team at Chung-Ang University Hospital proves the effectiveness and safety of ‘low-dose prasugrel’
A cerebral aneurysm is a disease in which a cerebral artery abnormally swells up and bulges like a ball. However, it is called a time bomb in the head because the symptoms are not clear until the rupture. still A cerebral aneurysm can be cured if it is detected before it ruptures and treated appropriately.That’s what experts say.
Fortunately If a cerebral aneurysm is discovered before rupture, coil embolization is performed if surgery is necessary considering the location and size of the cerebral aneurysm.can do. This is a procedure in which a coil is inserted into a swollen blood vessel and blood flow is blocked. At this time, according to the endovascular procedure In order to lower the risk of thrombosis, antithrombotic agents such as ‘Prasugrel’ are administered, but in elderly patients, the risk of thrombosis is rather increased due to atherosclerosis of blood vessels, so safe and effective antithrombotic agents are administeredThere have always been concerns regarding
Under these circumstances, a recent research team Announcement of research results proving the safety and effectiveness of low-dose prasugrel therapy in elderly patientsdid.
Chung-Ang University Hospital’s neurosurgery research team at the Cerebrovascular Center ((Professor Lee Shin-heon of Neurosurgery (first author), Professor Choi Hyeon-ho (responsible author), Nam Taek-gyun, head of the Cerebrovascular Center)) recently Proof of safety and effectiveness of low-dose prasugrel therapy in the treatment of unruptured cerebral aneurysm patients aged 75 years or olderHe said he had published a research paper.
Among 200 patients with unruptured cerebral aneurysm who received dual antiplatelet therapy including low-dose prasugrel before the procedure, the research team compared and analyzed the treatment results following coil embolization in elderly patients aged 75 years or older and control patients aged less than 75 years.
As a result, complications such as thromboembolism (7 patients, 3.5%) and hemorrhage (2 patients, 1.0%) occurred in only 9 (4.5%) of all unruptured cerebral aneurysm patients, and 2.6% (75%) of the elderly group aged 75 years or older. The control group under the age of 5 was 5.0%, and no significant difference was found between the two groups in the complication rate.
In addition, it was confirmed that there was no significant difference in complication rates between the elderly group aged 75 years or older (0%) and the control group younger than 75 years old (1.6%) in patients who received stent-assisted surgery during coil embolization.
Professor Lee Shin-heon of the Cerebrovascular Center of Chung-Ang University Hospital said, “Through this study, The safety and effectiveness of the treatment of elderly patients with unruptured cerebral aneurysms were proven by confirming that there was no difference in the incidence of complications between patients aged 75 years or older and patients younger than 75 years who received coil embolization treatment by administering low-dose prasugrel.I did it,” he said.
Chung-Ang University Hospital Cerebrovascular Center Professor Choi Hyeon-ho said, “Antithrombotic agents administered during coil embolization in elderly patients with cerebral aneurysms are safe and effective“With this study, Even in elderly patients over 75 years of age, low-dose prasugrel therapy can lower the risk of thromboembolism and reduce bleeding complications during coil embolization, which is expected to enable active treatment of cerebral aneurysms.it does,” he said.
Meanwhile, this research paper was published in the latest issue of ‘Clinical Neuroradiology,’ an SCI-level international journal, and in recognition of the excellence of the paper, Professor Lee Shin-heon of the Department of Neurosurgery received the Namcheon Academic Award from the Korean Society of Geriatric Neurosurgery on March 12. did.
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