The brain is healthy only when the body is healthy, the secret of Myokine

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Kang Rok Choi mental health specialist
Sadang Forest Department of Mental Health ledger

Psychiatric Newspaper | Choi Kang-rok, Department of Psychiatry Specialist

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How much do you move and exercise every day? There are not many things to use the body in the daily life of modern people who spend a lot of time indoors. This is especially true for students who sit at a desk all day studying or office workers who work while staring at a monitor in the office. The same goes for doing things that use your body but keep standing in the same spot or doing things that only use certain muscles repeatedly. Unless you deliberately move your body and make an effort to exercise, it is not easy to fill all the amount of exercise your body needs in everyday life.

Physically, it is relatively healthy, and until young adolescence or early adulthood, the body condition is maintained to some extent even with this lifestyle, but as you get older, you experience a decrease in muscle and an increase in fat. So it seems that the older you get, the more you say that exercise and diet are the best health secrets.

however The fact that exercise not only affects the health of the body, but also affects the health of the brain, Did you know? In general, exercise is known to have a positive effect on health by increasing muscle mass and blood flow, boosting immunity, and reducing stress. However, exercise can affect not only the net function in this physical aspect, but also brain health. More precisely, this happens through ‘myokines’ secreted from muscles through exercise.

Muscles not only protect the skeleton, but also secrete numerous physiologically active substances, which are collectively referred to as ‘myokines’. Myokine secretion increases as muscle contraction occurs during exercise, and the required message is delivered to various parts of the brain through ‘signaling molecules’.do. As a result Brain growth factor is activated by promoting the growth and generation of nerve cells (neurogenesi) and neuroplasticity (neuroplasticity)It’s possible.

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Adiponetic, a type of myokine, is known to prevent diabetes and arteriosclerosis through lipolysis. Recently, research results have been reported that adiponectin promotes hippocampal neurogenesis. Studies are continuing that other myokines, irisin and IGF-1, also affect cognitive function improvement and cranial nerve activation.

Irisin was first reported by the Dana-Farber Cancer Institute at Harvard Medical School in 2012, and it was found to have an effect on improving cognitive decline in Parkinson’s disease. Parkinson’s disease is a disease that occurs when the neurons involved in dopamine secretion decrease in the substantia nigra of the brain, and is characterized by involuntary tremors, muscle stiffness, and slowness of movement. A lack of irisin affects motor function, aging, and cognitive decline in Alzheimer’s disease.

Continuous research is being conducted on the role of various types of myokines in the body and how they are related to brain function, but more research is still needed. In addition, drugs that improve brain function using myokines are also in the early stages of research, and it is expected that it will take a considerable amount of time before they are commercialized. Even if it is commercialized, there is a prospect that it will be limited in general use due to its high price.

so that Experts say that exercise is a more realistic and effective method than increasing myokines through drugs.do. By preventing muscle mass loss through continuous exercise, you can obtain physical benefits such as immunity enhancement, stress reduction, and blood circulation promotion, as well as emotional control effects such as improvement in cognitive function and reduction of depression.is that. In particular, exercise is important for cognitive decline and musculoskeletal weakness in the elderly following middle age. This is because exercise plays a big role in preventing memory loss, dementia, and vascular disease.

In addition, not only the elderly, but also individuals in their growth and adulthood should develop muscle strength and activate their brain nerves through steady exercise. Sitting in front of a desk for a long time, studying or working without a break, we use our brain. In the meantime, our brain is prone to overload, and on the contrary, a body lacking exercise will prevent the musculoskeletal system from growing properly or balancing itself. The increase in obesity rates in children and adolescents and in adults in Korea is closely related to these lifestyles.

But our brain needs rest. While exercising and resting the brain, the muscles are diligently moving and working. And myokine, which is secreted through muscle contraction, stimulates the brain once more and helps the brain work more healthily and effectively. It is a virtuous cycle between the body and the brain. In this virtuous cycle, our bodies, cognitions, emotions, and behaviors find balance and maintain optimal conditions.

“A healthy mind resides in a healthy body.”There is a Roman aphorism called It seems to be even more so when we look at the relationship between exercise and muscles, myokines and the brain. When this word first appeared, the Romans were probably unaware of the existence and function of the Maica. Juvenal is said to have written this aphorism following seeing the Romans who valued only physical strength and neglected the mental part. I guess the Romans at the time were more familiar with the dualistic idea that the body and mind were separated.

However, through the secrets of the Myoka, we learn that body and mind, body and brain are never separate, they are in harmony and are closely related to each other. That is why the meaning of the phrase “a healthy mind dwells in a healthy body” seems to be coming to us today. Remembering Juvenal’s aphorism, why don’t you also grow your body muscles and brain muscles through regular and steady exercise?

Sadangsup Mental Health Clinic | Director Kang Rok Choi

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