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Intermittent fasting: does it boost our “good genes”?
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Intermittent fasting: an activation of the “good genes”?
The scientific literature clearly indicates the many health benefits of intermittent fasting, but we still know little regarding its mechanisms of action. A recent study indicates that these benefits are partly explained by a ” deep impact » of intermittent fasting on the expression of our genes, in particular those having a major role in hormonal regulation.
According to a recent study conducted on mice by an independent organization specializing in biological research (the Salk Institute located in San Diego in the United States), intermittent fasting would beneficially reshape gene expression throughout our bodies. This practice, which consists of abstaining from food every day (or at least several days a week) over a period of several hours, has been shown, in mice, to influence the expression of genes from more than 22 areas. of body and brain.
A strong impact on hormonal regulation
After analyzing the tissues of two groups of mice, including one subjected to intermittent fasting for seven weeks, the researchers found that this practice influences almost 80% of mouse genes (including genes located in our liver, intestines or brain).
Certain organs such as the adrenal glands, the liver or the hypothalamus, all organs that play a major role in the regulation of our hormones, seem more affected by this practice. For example, the liver metabolizes cholesterol better, bile acids, ketone bodies, and skeletal muscles (which control the central nervous system) regenerate more easily and metabolize glucose better.
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Better synchronization of organs with each other
Another interesting effect observed is the harmonization of the circadian rhythms of several organs of the body. Each organ, having its own internal clock, seemed better synchronize with other organs which would allow the body to better coordinate different processes ».
Finally, in the intestines, intermittent fasting seems to particularly affect the duodenum and jejunum (the two upper parts of the small intestine), and not the ileum (the lower part of the small intestine). For researchers, this means that new research might be carried out to understand the action of staggered meals on cancers and other diseases of the digestive tract.
If these results remain to be confirmed by future studies, they suggest that in the future intermittent fasting might prove useful in supporting diseases such as diabetes, atherosclerosis or chronic kidney disease.
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Bibliographic references 
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