“Dr. Anan” reveals the mutated virus Change yourself without focusing on escaping the landscape. But focusing on the ability to bind the ACE2 receptor protein on the cell surface is more scary than the good escape type.
Dr. Anant Chongkaewwatana Director of Animal Health Innovation and Management Research Group National Center for Genetic Engineering and Biotechnology (Biotech) posted a Facebook page. Anan Jongkaewwattana regarding a mutant virus that changes itself Until it spreads faster, stating that
The SARS-CoV-2 virus that escapes immunity is a change in one’s appearance. until the antibodies in our body remember the old virus can’t remember new makes it easy for the virus to enter the body This one is straightforward.
Issues with questions About a virus that changes itself in a way that doesn’t focus on escaping the landscape but focused on the ability to bind ACE2 receptor proteins on the cell surface well. How will it affect the virus? Because if the antibody binds even though it binds the receptor protein well have no chance of reaching that cell anyway
Like the case of BA.2.75 that I talked regarding yesterday’s Oxford research that The virus chooses to make itself more tightly attached to the cell (9 times compared to the original BA.2) instead of making itself able to escape the immune system.
answer to this question Explained from an article Published in the journal npj vaccines several months ago.
Imagine the mechanism of action of an antibody in our body: binding to the virus spike protein in the same location as the spike binding to the receptor protein.
Normally, nature makes antibodies. to grip specific spikes and much tighter than the receptor protein But if the thorn spike changes itself It binds to the receptor protein many times tighter, perhaps even stronger than the antibody’s ability to bind to the spike spike.
together with the change of Spike to some degree that reduces the binding properties of antibodies that were previously very specific and tightly packed.
This will be an important factor for the virus to more easily infect the cells. Although our body has some antibodies that can catch the virus. (The virus doesn’t escape the landscape.)
According to this idea, if the virus transforms itself to become more and more highly bound to the receptor protein to such a level that the antibody is really overpowered, how many antibodies are there? From vaccination or infection, it may not be useful.
But the information right now we are not at that point yet. And that’s why scientists would be more concerned with this kind of self-switching virus than it is to escape antibodies.
because of the latter Our body makes new antibodies. specific to which the resulting changes can be handled But first, it has to create a more tightly bonded antibody, which is much more difficult.
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