◀Anchor▶
Of course, it is an organ abnormality in severe cases
Rheumatoid arthritis with cognitive impairment
In the meantime, the focus has only been on the relief of inflammation.
There was.
Cognitive impairment and cognitive impairment
Simultaneous treatment opened the way.
Treatment includes dementia drugs in clinical trials
It is getting more and more attention.
Reporter Cho Hyung-chan reports.
◀Report▶
Rheumatoid arthritis is genetic and environmental
Beyond immunity, we need to protect our body
Inflammation and inflammation as immune cells flock to the joints
It is an autoimmune disease that causes damage.
Scleritis, interstitial pneumonia, and purpura
Accompanying, the inflammatory response also affects the brain,
May cause depression and cognitive impairment
The cause has been a labyrinth.
A Korean research team found that patients with rheumatoid arthritis
Coexist in joints and star cells in the brain
Maobi enzyme is the common pathogenesis of both diseases
He was the first to discover that he was a human being.
Maobi inhibits signal transduction in nerve cells.
It activates a neurotransmitter called GABA.
If ‘KDS2010’, which inhibits Maobi, is administered, joint inflammation as well as cognitive function are recovered.
will.
Woojin Won / Researcher, Center for Cognitive Sociality, Institute for Basic Science
“Previous studies have shown that immune cells and
If the focus was on lowering the inflammatory
The target mechanism has now been revealed.”
This has also been confirmed through animal experiments.
KDS2010 is currently used for Alzheimer’s and other dementias.
It is receiving more attention as it is undergoing clinical trials as a treatment
there is.
Simultaneous treatment of arthritis, cognitive impairment and dementia
Length of development of possible next-generation rheumatoid treatment
It’s open.
Chang-Jun Lee / Director, Center for Cognitive and Social Studies, Institute of Basic Science
“In dementia, we found that the Maobi of reactive star cells
Because it has been shown that enzymes are the cause
When this is suppressed by the same mechanism
Rheumatoid Animals as Dementia Animal Models
Cognitive impairment was improved by inhibition in the model
It’s done.”
The results of this study were published in the world’s top 10 molecular medicine magazine.
Official Journal of the Korean Society for Biochemical and Molecular Biology
It was published in ‘Experimental Molecular Medicine’.
This is Jo Hyung-chan from MBC News.
(Video coverage: Shin Shin-ho)
