go run University of Buffalo Scholars A study whose results show the possibility of reversing the aging process in muscle cells. Aging in muscle cells occurs when the ability of the cell to divide and repair itself is reduced or diminished, which is known as cellular aging. The study found that by overexpressing a specific protein called NANOG, the cell might be reset to a different state to reverse aging.
cellular aging
Cellular aging occurs when cells reach a point where they are no longer able to repair themselves and cannot divide. The genetic material inside the cell becomes unstable, leading to cell deterioration and disease. And then the entire body stops regenerating cells over time.
different technology
Previous attempts to reverse aging in cells have focused on returning the cell to a stem-cell-like state. But the new technology, invented in the latest study, takes a completely different path, literally helping the cell return to its remodeling process to regain full functionality.
Scientists have discovered an important role for a protein known as NANOG in aging human muscle cells, which by overexpressing it, or in other words exciting it, were able to reverse age-related cell degradation and increase the cells’ DNA repair mechanisms.
Cell rejuvenation
Most intriguing, the researchers explain, when NANOG was overexpressed in prematurely aged lab mice, the number of muscle stem cells increased, reconfirming the results of the lab study on human muscle cells, implying that NANOG was overexpressed. It gives it regeneration and repair properties of aging cells.
The study’s lead researcher, Professor Stelios Andreades, said that skeletal muscle is a highly regenerative organ that makes up regarding 45% of the total body mass and contributes to the ease of skeletal movements as well as the regulation of metabolism.
The process of renewal, repair or new growth in the body in muscle tissue is carried out by the proliferation of muscle fibers, and therefore when activating muscle strains of origin, or the basic beginnings of muscle growth, they multiply, differentiate and contribute to the regenerative growth of damaged muscle fibers.
Reproduction indefinitely
And Professor Andradis pointed out that one of the challenges facing his research team at the current stage is that the NANOG protein did not multiply indefinitely, as the cumulative cell numbers following regarding 20 or 25 days of overexpression witnessed a state of stability, explaining that this problem It is not the ultimate in the search for ways to rejuvenate, but it sets a cornerstone that motivates us to continue discovering other ways to overcome the aging process indefinitely.