Does pregnancy make colorectal cancer worse? Qian Zhenghong, a gastrointestinal, hepatobiliary physician at Keelung Chang Gung Hospital, said that research has found that pregnancy can reduce the risk of colorectal cancer; because pregnancy increases estrogen by 10 times, and “estrogen has an anti-cancer effect on the colon,” but pregnancy also increases insulin. secretion, and insulin resistance increases colorectal cancer risk, so the good and the bad outweigh, pregnancy reduces colorectal cancer risk by 9%!
Colorectal Cancer Myth Debunked
According to a German study recently published in the journal JNCI cancer Spectrum, researchers included 2,650 adult women with colorectal cancer and 2,175 healthy women of the same age as a control group. The analysis found that having a pregnancy reduced the risk of colorectal cancer by 9%, especially right-sided colorectal cancer.
Breastfeeding for more than a year reduces the risk of colorectal cancer by 26%, especially right-sided colorectal cancer. Using birth control pills for more than 9 years reduces the risk of colorectal cancer by 25%, especially left-sided colorectal and rectal cancer. Using hormone supplements to treat menopause reduces the risk of colorectal cancer by 24%. In addition, the age of first menstruation has nothing to do with the occurrence of colorectal cancer. Entering menopause following age 50 reduces the risk of colorectal cancer by 17%.
Pregnancy reduces colorectal cancer risk by 9%
Qian Zhenghong pointed out that the research theme is mainly to analyze the effects of physiological female hormones and external supplementary hormones on the occurrence of colorectal cancer. Pregnancy will increase estrogen by 10 times, and “estrogen has protective and anti-cancer effects on the large intestine”, but pregnancy will also increase insulin secretion at the same time, and insulin resistance will increase the risk of colorectal cancer. Statistically, pregnancy reduces the risk of colorectal cancer, but only by 9%.
The study also pointed out that hormone supplementation in menopausal women can reduce the risk of colorectal cancer, mainly because there are estrogen receptors on the colorectal cells, and the local estrogen concentration in the large intestine increases, which can reduce the production of carcinogenic secondary bile acids and reduce the damage of colorectal DNA. and mutations, and inhibition of cell proliferation in colorectal tumors.
But there are other problems with hormone supplementation, such as a possible increased risk of coronary artery disease, breast cancer and stroke, so hormone therapy is not yet suitable as a way to fight colorectal cancer.
Qian Zhenghong finally added that people do not need to change their fertility plans because of the research results, and through this type of research, some myths can be solved. For example, the age of first menstruation has nothing to do with colorectal cancer, and hormone supplementation will not cause colorectal cancer. cancer.
◎ Image source/Provided by Dazhi Image/shutterstock
◎ Source/Dr. Qian Zhenghong
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