[의학신문·일간보사=정광성 인턴기자] A study by a Korean research team is noteworthy as a result of a study showing that the lower the age of menopause during early menopause increases the risk of heart failure and atrial fibrillation.
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The team of Professor Nam Ga-eun of the Department of Family Medicine at Korea University Guro Hospital (first author, Professor Ji-in Shin of Department of Family Medicine at Korea University Guro Hospital, Professor Kyung-do Han of the Department of Information Statistics and Actuarial Science at Soongsil University, co-author Dr. Jin-hyeong Jung of the Sungkyunkwan University Medical Research Institute, etc.) increased the risk of heart failure and atrial fibrillation.
According to the professor’s team, cardiovascular disease is generally known to be more common in men than in women. This is because the female hormone estrogen protects the cardiovascular system, and estrogen secretion decreases following menopause. Therefore, there have been studies investigating the relationship between past menopause age and cardiovascular disease.
However, the majority of studies were conducted on Western women, or studies on the relationship with overall cardiovascular disease had limitations.
Accordingly, Professor Nam Ga-eun’s team followed-up 1,401,175 postmenopausal women over the age of 30 who underwent a health checkup from the National Health Insurance Corporation in 2009 for an average of 9.1 years until the end of 2018.
As a result of observation, regarding 2% of the subjects, or 28,111, had early menopause before the age of 40, and the average age of menopause was 36.7 years for women who experienced early menopause.
During this period, 3.0% (42,699) and 3.2% (44,834) of all subjects developed heart failure and atrial fibrillation, and women with early menopause had a 33% higher risk of heart failure and atrial fibrillation, respectively, than those who did not. It was found to increase by 9%.
The risk of heart failure and atrial fibrillation also increased with decreasing age at menopause. Compared with women who had menopause following age 50, women aged 45 to 49, 40 to 44, and under 40 at menopause had an 11%, 23%, and 39% risk of heart failure, respectively, 4% and 10% for atrial fibrillation, respectively. , an 11% higher risk of occurrence, the professor’s team explained.
The results are adjusted for age, smoking, drinking, physical activity, chronic diseases (hypertension, type 2 diabetes, dyslipidemia, chronic kidney disease, coronary artery disease, etc.), menopause hormone therapy, and age of menarche.
Professor Nam Ga-eun said, “The results of this study suggest that female fertility needs to be considered along with traditional risk factors for cardiovascular disease. It will be able to motivate people to prevent cardiovascular diseases, such as improving their lifestyle related to harm.”
Meanwhile, the results of this study were published in the August issue of ‘European Heart Journal’, the official journal of the European Heart Association (ESC), and it is known that it received global attention.
