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Al-Qaeda leader Ayman al-Zawahiri was killed in a US raid inside Afghanistan, according to US media.
It is believed that al-Zawahiri was killed in a drone strike on Sunday.
There was no official confirmation, but the White House said that US President Joe Biden will give details of an operation inside Afghanistan in the coming hours.
Al-Zawahiri, who helped found the Egyptian Jihad, took over the leadership of al-Qaeda following the killing of Osama bin Laden at the hands of US forces on May 2, 2011.