The research team led by Professor Young-Dan Cho of the Department of Periodontology at Seoul National University Dental Hospital and Professor William.V.Giannobile, the Dean of Harvard Dental School in the U.S., researched the improvement of bone regeneration using the bone morphogenetic protein (BMP) gene fixation technique on the surface of dental implants to dramatically reduce implant treatment time. suggested a way to shorten it.
This research was carried out with support from the National Institutes of Health and the Swiss Osteology Research Foundation. has been published
Treatment methods using BMP (bone morphogenetic protein) are used in clinical practice to make the implant adhere well to the gum bone and are commercially available in the form of protein. didn’t A method using the BMP gene has also been developed to provide a stable supply of BMP and enhance the effect, but if the gene applied to the surgical site is not fixed, it flows along the blood to other tissues, causing serious problems in forming bones.
A joint research team at Seoul National University Dental Hospital and Harvard College of Dentistry conducted experiments in cell experiments and mouse implant models by fixing the BMP7 gene on the titanium implant surface using CVD (Chemical Vapor Deposition) technology. It was verified that the BMP7 protein was stably produced on the surface of the BMP7 gene-coated titanium, and through this, it was confirmed that the differentiation of osteoblasts was enhanced and the bone regeneration ability was increased.
Professor Young-Dan Cho said, “It takes at least three months for bones to stably attach to the surface of titanium SLA (sandblasted, large grit, acid-etched), which is currently most used. Through application, it will be possible to reduce the discomfort of patients by shortening the period without teeth, and furthermore, the BMP gene fixation method can be applied to bone graft materials.”
