Mice gain waist fat on a 30-week high-fat diet and reduce brain shrinkage and damage in diabetes
Consuming fatty foods for a long time can increase your waist circumference and cause brain damage, a new study has found.
A joint study between the University of South Australia (UniSA) in Australia and the University of Kunming Medical School in China found that eating a diet high in fat for a long period of time in mice might lead to brain damage as well as becoming obese. The researchers found that mice that ate a high-fat diet for 30 weeks developed obesity and diabetes, which was associated with cognitive decline, such as anxiety, depression and Alzheimer’s disease.
“This study reinforces the evidence supporting a link between chronic obesity and diabetes and Alzheimer’s disease,” said Larisa Bobrovskaya, associate professor of neurochemistry and biochemistry at the University of South Australia, the lead author of the study. Obesity and diabetes have been shown to damage the central nervous system, leading to psychiatric disorders and reduced cognitive function. “Obese patients have an approximately 55% increased risk of developing depression, and the risk of developing diabetes will approximately double this proportion,” she added. Alzheimer’s disease is expected to reach 100 million by 2050.
The researchers randomly assigned mice aged 8 weeks or older to either a standard diet group or a high-fat diet group for 30 weeks. They also observed and analyzed food intake, body weight, and blood sugar levels in these mice. Rats fed the high-fat diet gained more weight than mice fed the standard diet, developed insulin resistance, and began to behave abnormally. When mice with genetically modified Alzheimer’s disease were fed a high-fat diet, their brain’s cognitive function plummeted and pathological changes were evident. The researchers found that the combination of obesity, aging and diabetes was significantly more likely to lead to cognitive decline, Alzheimer’s disease and other mental health disorders.
The results of this study (Long term high fat diet induces metabolic disorders and aggravates behavioral disorders and cognitive deficits in MAPT P301L transgenic mice) were published in the journal Metabolic Brain Disease and the American health medical media MedicalXpress. has introduced
By Kim Young-seop, staff reporter edwdkim@kormedi.com
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