Medical Genome Center Keep an eye on the “Omicron” subspecies BA.4, BA.5 and BA.2.12.1, as they tend to show more severe symptoms in the infected than the original strain. reiterated the need for vaccinations
On May 7, 2022, the Facebook fan page Center for Medical Genomics of the Medical Genomics Center Faculty of Medicine Ramathibodi Hospital posted a message regarding Omikron Surveillance subspecies that may cause inflammation of the lung tissue The same is true for the “delta” strains that have spread in the past.
It states that mutations in the coronavirus genome strand at the spike gene at “452” may be a contributing factor. The “omicron subspecies BA.4, BA.5, and BA.2.12.1” that the WHO monitors have the ability to have high transmissibility and may have connectivity properties. Cell wall (lung) from multiple cells into a single cell. The fusogenicity, or multinucleated syncytial pneumocytes, can cause inflammation of the lung tissue, as is the case with past outbreaks of “delta” strains.
The entire genome of the 2019 novel coronavirus found a change in the thorn region at “452” from the amino acid “leucine (L)” to “arginine (R)” or “A”. Lutamine (Q)” gives the spines properties that can connect neighboring cell walls. Cell fusion or syncytia formation allows the virus to rapidly spread cell-to-cell without leaving the cell at risk of being captured and destroyed by “antibodies” built into the cell. The body of a person who has been infected naturally and through vaccination. Infected multinucleated syncytial pneumocytes, infected multinucleated syncytial pneumocytes become large cells within a multinucleated cell. The DNA inside these cells is broken and broken. This makes the immune system of the infected person look foreign and destroys those multinucleated cells. inflammation and in some cases, it develops into pneumonia, which can cause severe illness in the infected person.
The “delta” strain has a thorn mutation to “R452” causing severe infections. This is partly due to pneumonia caused by the fusion of several infected cells into one cell.
In contrast to the original omicron strains (B.1.1529) such as BA.1, BA.1.1 and BA.2, there is nomutatethe area The amino acid remains “L452”, consistent with the clinical manifestations of the original omikron strain. with mild symptoms One reason may be that syncytial pneumocytes are not formed in the infected lung cells.
But the concern is Both the omikron subspecies “BA.4” and “BA.5”, which the WHO declared as an outbreak in South Africa, were mutated in the R452, while the BA.2.12.1 subspecies was the epidemic. In the United States, the “Q452” mutation is reversible to the “delta” strain, potentially causing multiple infectious cells to fuse into one.
The spike protein of Omikron subspecies BA.2 was more similar to subspecies BA.2.12.1, BA.4, and BA.5 than subspecies BA.1. Infection with subspecies BA.2 is likely to prevent infection with subspecies BA.2.12.1, BA.4, and BA.5 more than those from subspecies BA.1. Outbreaks of the BA.1 subspecies have long been followed by the BA.2 subspecies, but the BA.4 and BA.5 subspecies can still be found in South Africa. And subspecies BA.2.12.1 can spread in the United States. This suggests that mutations on the genome line of the BA.4, BA.5, and BA.2.12.1 subspecies at the “452” position are likely to be a key factor in promoting the spread.
