Professor Jae-beom Kim, Department of Life Sciences, Seoul National University, etc. Published in the international academic journal ‘Cell Metabolism’
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(Seoul = Yonhap News) Reporter Woo-seong Yoon = A process has been identified that obesity accelerates the aging of visceral fat cells, leading to metabolic diseases such as diabetes, hyperlipidemia, and cardiovascular disease.
Seoul National University, Professor Jae-beom Kim of the Department of Life Sciences, announced on the 3rd that they have identified the cause of rapid aging of fat cells during obesity and the process of metabolic diseases caused by aging fat cells.
According to the research results, it was found that the DNA damage accumulated due to obesity induces the aging phenomenon of visceral fat cells to accelerate, and causes metabolic diseases such as adipose tissue inflammatory response and insulin resistance through abnormal secretion function.
The research team also found that the SREBP1c protein has a protective action once morest cellular aging by mediating the repair of DNA damage in adipocytes.
The researchers described this as a key finding in the development of treatments for obesity-related metabolic diseases.
Although it has been known that there is a high correlation between cellular aging and the onset of metabolic diseases, the relationship between obesity and cellular aging or the cause of aging has not been identified.
The results of this research were first published online in ‘Cell Metabolism’, an international academic journal in the field of biology and energy metabolism, and will be published in the May issue.
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