The vaccine for children aged 6 to 11 will be launched on May 2, and there are still doubts in the outside world. (Schematic diagram of vaccine administration).Figure: New head shell data photo
The Moderna vaccine for 6-11 years old will start today (2), and the BNT vaccine in children’s dosage form will also be available in the future. However, many parents are still hesitating whether to let their children vaccinate, or which brand to choose. The current Miaoli Daqian Medical Yang Zhijun, director of the system’s cardiovascular surgery department, said on Facebook a few days ago, “Not just the Moderna vaccine, but all mRNA vaccines including BNT. I don’t currently consider giving my children a shot.”
Yang Zhijun explained that the mRNA vaccine is a brand-new vaccine development technology. The first product to be put into actual combat is COVID. His principle is to send a piece of artificial “messenger RNA” into immune cells and let them produce antigens. He gave an example, “It’s like you throw the menu, dumpling skin and pork stuffing to McDonald’s and ask him to steam the dumplings.” This is like a kind of “cell therapy” targeting immune cells. capacity of cells. Is this risky? “Theoretically no, because human cells do not have reverse transcriptase, so mRNA theoretically does not change the DNA structure of cells. It means that McDonald’s steamed dumplings are steamed, and they will not mutate into Din Tai Fung one day.”
Yang Zhijun said that the adult immune system has developed and stabilized, and theoretically, the impact should not be large, but everything is only “theoretical”. But it is different for children. The immune system of young children is developing. Moreover, mRNA will not only enter and change T cells, but also enter long-term memory B cells. Children’s immature bone marrow stem cells are also very strong. The protective power of mRNA vaccine once morest COVID-19 , Judging from the evidence, it is probably related to the dose. The more the dose, the more mRNA sent in, the greater the response and the stronger the protection. Playing less, of course, has fewer side effects and weaker protection.
He said, “When you are entangled in the label and spinning around these numbers, have you ever stopped and thought: Wait, should we put the mRNA vaccine on the child?” Decision-making always considers the risks and disadvantages. Besides the serious side effects of 1 in 10,000, the risk of hitting mRNA is unknown.
He mentioned that in his outpatient clinic, there were many patients with chest tightness and discomfort. A patient with chronic diseases and dialysis, who was originally in stable condition, passed away recently following being vaccinated. In addition, some reports show that following vaccination, the original stable cancer suddenly relapsed and out of control, and there are also reports of sudden immune diseases such as leukemia and lupus erythematosus following vaccination. So far, humans have no ability to know whether the occurrence of these diseases is related to mRNA vaccines.
In the end, he said, when there is a risk of an option that is relatively manageable, and the hidden risk of another option is limited, I decided to use our limited knowledge to help my child choose the one that is more risk-tolerant. “My logic is to focus on not harming the body first, and then focus on the effect. For mRNA vaccines, this technology is too new, and I really don’t understand it. Therefore, if we have a choice, we would rather choose a relatively mature protein vaccine technology.”
