Thairath Online
29 Apr 2022 13:00
Virologist reveals research “male patient” infect “Covid-19“ More likely to have severe symptoms “Female patient” especially the elderly
On April 29, 6565, Dr. Anan Chongkaewwatana, a biotech virologist, NSTDA, posted a message via Facebook stating that the information of COVID-19 patients with severe symptoms More likely to be male than female especially the elderly male Chances of contracting COVID and severe symptoms more than any other age group. which supports such observations An article published in the journal Immunology sums it up quite interestingly.
Men have hormones called Androgens, consisting of testosterone and dihydrotestosterone. in high quantity While females have higher levels of estrogen and progesterone than men. This hormonal difference It was found to have a direct effect on the ability to infect with the SARS-CoV-2 (COVID-19) virus.
For testosterone, it has an effect on increasing the expression of protein (TMPRSS2) that allows the virus to enter cells, while estrogen in women not only does not improve the virus’s entry into cells. It also stimulates the inhibition of ACE2 protein, a key receptor protein that enters viral cells. Makes important organs of men such as lungs, heart have higher expression of ACE2 than women.
Another interesting aspect is that estrogen has been found to play a key role in the formation of a protein called TLR7 that detects viral infection more quickly and well. As a result, the body responds to infection better than men. The chance that the virus will multiply following it enters the body is slower.
In addition, men have a higher ratio of neutrophil white blood cells, which is a type of white blood cell. be the main character that causes severe pneumonia in COVID patients They have fewer levels of the key white blood cells, either B cells or T cells, than women. Overall, nature provides women with more defense mechanisms once morest SARS-CoV-2 infection than men on many levels.
Thanks for the Facebook information Anan Jongkaewwattana.
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