2023-10-12 06:00:12
Caffeine was already known to reduce neuronal inflammation. It is also suspected of playing a potential protective role against neurodegenerative diseases, without really understanding the interactions. A recent study confirms these assumptions, revealing that the consumption of caffeine can actually reduce the risk of developing this disease. functions or health of a living organism, animal, etc.) for carriers of certain risk variants, including in the case of genetic predisposition (A genetic predisposition is the genetic configuration of an organism…).
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As part of this study conducted by the National Institute of Neurosciences (Neurosciences correspond to all biological disciplines and…), 4,488 people were asked to complete a questionnaire (Questionnaires are one of the tools for research for the human and social sciences, in…) relating to their consumption of coffee or tea. Among these participants, 1,790 had Parkinson’s disease (Parkinson’s disease is a chronic neurological disease affecting the nervous system…) and 2,698 served as controls. All participants had a specific genetic variant, LRRK2, which is seen mainly in Asia. or Eastern Afro-Eurasia, and which increases the risk of developing Parkinson’s disease by 1.5 to 2 times.
On average, participants who had already developed Parkinson’s disease consumed 448.3 mg of caffeine, and the others consumed 473 mg (the equivalent of 4 to 5 cups of Arabica coffee consumed in the countries (Country comes from the Latin pagus which designated a territorial and tribal subdivision of extent…) Western, or 2 cups of coffee usually served in Singapore).
By comparing the participants’ reported caffeine consumption and the progression of the disease over time, the researchers were able to identify its benefits on the development of the disease. The benefits would increase proportionally with consumption, but researchers consider that a consumption of 400 mg per day would be ideal. for most healthy adults (Health is a state of complete physical, mental and social well-being, and does not consist of…). They also specify that asymptomatic carriers of the LRRK2 variant who do not consume caffeine have a risk of developing Parkinson’s disease 4 to 8 times greater than coffee or tea drinkers.
To date, the interaction of caffeine with genes has not yet been clearly identified. Scientists assume that the neuroprotective effect of caffeine influencing the protein LRRK2, could be explained by the impact it plays (The cheek is the part of the face which covers the oral cavity, closed by the…) on the adenosine receptor (Adenosine is a nucleoside formed when adenine is attached to…) A2A. But additional research will be necessary to better understand the mechanism.
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